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Furthermore, legume-derived flavonoids also have a positive impact on gut health, manipulating the prevention and treatment of chronic diseases such as cardiovascular diseases, type 2 diabetes (T2DM), obesity, cancer, and inflammatory diseases (Clemente & Olias, 2017)

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In addition, TMAO significantly promoted ischemic-induced VA by modifying the left stellate ganglion (LSG) either directly or through the gut-brain-heart axis (125)